Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?

…, JM Andrews, D Krumbiegel - Official journal of the …, 2013 - journals.lww.com
Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal (GI) tract
characterized by pain or discomfort from the lower abdominal region, which is associated with …

Cordycepin is an Immunoregulatory Active Ingredient of Cordyceps sinensis

…, W Dressel, G Shadier, D Krumbiegel… - The American Journal …, 2008 - World Scientific
We have reported that cordycepin, an adenosine derivative from the fungus Cordyceps,
increased interleukin (IL)-10 expression, decreased IL-2 expression and suppressed T …

Combined Toll-like receptor agonists synergistically increase production of inflammatory cytokines in human neonatal dendritic cells

D Krumbiegel, F Zepp, CU Meyer - Human immunology, 2007 - Elsevier
Dendritic cells (DC) are thought to be responsible for the reduced ability of human
newborns to induce protective T-helper 1 (Th1) immune responses. The key player in Th1 …

Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients

…, JM Andrews, H Zola, D Krumbiegel - Brain, Behavior, and …, 2014 - Elsevier
Alterations in the neuro-immune axis contribute toward viscerosensory nerve sensitivity and
symptoms in Irritable Bowel Syndrome (IBS). Inhibitory factors secreted from immune cells …

CD4+ and CD8+ Regulatory T Cells in Chronic Rhinosinusitis Mucosa

…, D Miljkovic, D Krumbiegel - American journal of …, 2014 - journals.sagepub.com
Background Chronic rhinosinusitis (CRS) mucosal inflammation is characterized by an
accumulation of effector–memory T cells, but their immune regulatory potential has not been …

Accumulation of Effector Memory CD8+ T Cells in Nasal Polyps

…, R Grose, H Zola, D Krumbiegel - American journal of …, 2013 - journals.sagepub.com
Background T lymphocytes are prevalent in sinus mucosa and are implicated in chronic
rhinosinusitis (CRS) pathogenesis. However, the major T-cell subpopulations, helper (CD4 + ) …

Peptidase inhibitor 16 identifies a human regulatory T‐cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes

…, D Campbell, CY Brown, D Krumbiegel… - European journal of …, 2019 - Wiley Online Library
CD4 + T‐cell subsets play a major role in the host response to infection, and a healthy immune
system requires a fine balance between reactivity and tolerance. This balance is in part …

PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20

…, TJ Sadlon, S To, H Zola, SC Barry, D Krumbiegel - Cellular …, 2012 - Elsevier
The peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed
by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th …

Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid …

N Ruzehaji, R Grose, D Krumbiegel, H Zola… - European Journal of …, 2012 - jle.com
Chronic non-healing wounds form a medical need which will expand as the population ages
and the obesity epidemic grows. Whilst the complex mechanisms underlying wound repair …

Enhanced expression of IL‐27 mRNA in human newborns

D Krumbiegel, C Anthogalidis‐Voss… - Pediatric allergy and …, 2008 - Wiley Online Library
Interleukin (IL)‐27, a heterodimer composed of Epstein–Barr virus‐induced gene 3 (EBI3)
and p28, is an early product of activated dendritic cells (DC). Binding of IL‐27 to the WSX‐1 …