Background Patients treated with methotrexate for rheumatoid arthritis often improve but
continue to have active disease. This study was undertaken to determine whether the addition …

… DJ Burge reviewed the progress of the study and coordinated the data management and
analysis. DJ Burge and PJ Mease wrote the paper; BS Goffe, J Metz, A VanderStoep, and B …

Background: In a phase II study, etanercept (recombinant human tumor necrosis factor
receptor [p75]:Fc fusion protein) safely produced rapid, dose-dependent improvement in …

Objective To evaluate the long‐term efficacy and safety of etanercept in children with juvenile
rheumatoid arthritis (JRA) participating in an ongoing multicenter, open‐label, extended‐…

Objective To evaluate the safety, efficacy, and pharmacokinetics of 50 mg etanercept
administered subcutaneously once weekly in adult patients with active rheumatoid arthritis (RA). …

OBJECTIVE: Therapeutics used to treat inflammatory diseases, including psoriatic arthritis (PsA),
may potentially interfere with normal immune system function. Immune system function …

OBJECTIVE: Patients with rheumatoid arthritis (RA) treated with etanercept (Enbrel) in controlled
studies of 3 to 6 months' duration had rapid and sustained improvement of their disease…

Objective To observe the long‐term safety and efficacy of combination therapy with etanercept
and methotrexate in patients with rheumatoid arthritis (RA), and to determine whether the …

Blood-borne RNA circulating in association with autoantibodies is a potent stimulator of
interferon production and immune system activation. RSLV-132 is a novel fully human biologic …

During the first half of this century rheumatic fever was a common disease with significant
morbidity and mortality in the United States. In the 1980s, when many clinicians were hoping …