[PDF][PDF] Association of anti–topoisomerase I antibodies of the IgM isotype with disease progression in anti–topoisomerase I–positive systemic sclerosis
…, N Ajmone Marsan, CM Wortel… - Arthritis & …, 2020 - Wiley Online Library
Objective Anti–topoisomerase I (anti–topo I) autoantibodies in systemic sclerosis (SSc) are
associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the …
associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the …
[HTML][HTML] Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
…, G Stoeken-Rijsbergen, LM Slot, CM Wortel… - Arthritis research & …, 2021 - Springer
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or
carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG …
carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG …
Association between centromere-and topoisomerase-specific immune responses and the degree of microangiopathy in systemic sclerosis
NM van Leeuwen, CM Wortel, CM Fehres… - The Journal of …, 2021 - jrheum.org
Objective. Autoreactive antibody responses, including the use of several isotypes of
autoantibodies, have been shown to be associated with clinical outcome in several rheumatic …
autoantibodies, have been shown to be associated with clinical outcome in several rheumatic …
Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis
CM Wortel, SIE Liem, NM van Leeuwen, M Boonstra… - RMD open, 2023 - rmdopen.bmj.com
Objectives Almost all patients with systemic sclerosis (SSc) harbour autoantibodies. Anti-topoisomerase
antibodies (ATA) and anti-centromere antibodies (ACA) are most prevalent and …
antibodies (ATA) and anti-centromere antibodies (ACA) are most prevalent and …
Presence of IgM anti-topoisomerase I antibodies is associated with disease progression in anti-topoisomerase I IgG positive systemic sclerosis
…, MK Ninaber, N Ajmone Marsan, CM Wortel… - Arthritis and …, 2020 - zora.uzh.ch
BACKGROUND: Anti-topoisomerase I auto-antibodies (ATA) in systemic sclerosis (SSc) are
associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the …
associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the …
[HTML][HTML] Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis: implications for disease pathogenesis
…, S Neppelenbroek, CM Fehres, C Wortel… - Seminars in arthritis and …, 2023 - Elsevier
A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence of autoreactive
B cell responses targeting nuclear proteins. Almost all SSc-patients harbour circulating …
B cell responses targeting nuclear proteins. Almost all SSc-patients harbour circulating …
AB1299 AN ONGOING ANTICENTROMERE ANTIBODY RESPONSE ASSOCIATES WITH PROGRESSION TOWARDS SYSTEMIC SCLEROSIS
N van Leeuwen, M Boonstra, J Bakker, C Wortel… - 2019 - ard.bmj.com
Background Although some dated studies suggest a possible association between clinical
characteristics and isotypes of anticentromere antibodies (ACA) in patients with systemic …
characteristics and isotypes of anticentromere antibodies (ACA) in patients with systemic …
[PDF][PDF] Machine learning analysis of the T cell receptor repertoire identifies sequence features of self-reactivity
The T cell receptor (TCR) determines specificity and affinity for both foreign and self-peptides
presented by the major histocompatibility complex (MHC). Although the strength of TCR …
presented by the major histocompatibility complex (MHC). Although the strength of TCR …
Airway mycosis in allergic airway disease
The allergic airway diseases, including chronic rhinosinusitis (CRS), asthma, allergic
bronchopulmonary mycosis (ABPM) and many others, comprise a heterogeneous collection of …
bronchopulmonary mycosis (ABPM) and many others, comprise a heterogeneous collection of …
SAT0310 ANTI-CENTROMERE ANTIBODY ISOTYPE LEVELS AS BIOMARKER FOR DISEASE PROGRESSION IN SUBJECTS AT RISK TO DEVELOP SYSTEMIC …
N Van Leeuwen, J Bakker, A Grummels, C Wortel… - 2020 - ard.bmj.com
Background: Presence of anti-centromere antibodies (ACA) generally associates with a better
prognosis than many other systemic sclerosis (SSc) associated autoantibodies. However, …
prognosis than many other systemic sclerosis (SSc) associated autoantibodies. However, …