C3 glomerulopathy is a recently introduced pathological entity whose original definition was
glomerular pathology characterized by C3 accumulation with absent or scanty …

Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children.
Mutations in one or more genes encoding complement-regulatory proteins have been …

The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

Exosomes are secreted nanometer‐sized vesicles derived from antigen‐presenting cells,
which have attracted recent interest as they likely play important roles in immune regulation, …

The complement system is a key component regulation influences susceptibility to age-related
macular degeneration, meningitis, and kidney disease. Variation includes genomic …

We examine whether attainment of goals at work is associated with enhanced affective well‐being
and whether attainment of personally more important goals has a stronger …

Dense deposit disease (DDD) is a severe renal disease characterized by accumulation of
electron-dense material in the mesangium and glomerular basement membrane. Previously, …

Common polymorphisms in complement alternative pathway (AP) proteins C3 (C3 R102G ),
factor B (fB R32Q ), and factor H (fH V62I ) are associated with age-related macular …

Objectives: To reduce gain in body mass index (BMI) in overweight/mildly obese children in
the primary care setting. Design: Randomized controlled trial (RCT) nested within a baseline …

Background. The effect of islet cell transplantation (ICT) on the progression of diabetic
microvascular complications is not well understood. Methods. We have conducted a prospective, …