Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and might be
mediated via the COX-2 enzyme. Previous studies with the selective COX-2 inhibitors, …

Background Aprepitant is a neurokinin 1 receptor antagonist that, in combination with a
corticosteroid and a 5‐hydroxytryptamine 3 receptor antagonist, has been shown to be very …

Background Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the
treatment of rheumatoid arthritis (RA). Methods Double-blind, randomized, placebo and active …

OBJECTIVE: To evaluate the efficacy and tolerability of the highly selective cyclooxygenase-2
(COX-2) inhibitor etoricoxib for the treatment of rheumatoid arthritis (RA). METHODS: A …

Methods: This study evaluated the calcitonin gene-related peptide (CGRP) receptor antagonist
telcagepant (tablet formulation) for treatment of a migraine attack and across four attacks. …

Visual evoked potentials (VEPs) to lateralised light flashes were recorded from two
acallosal patients. In one patient, these recordings were made while he performed a choice-reaction …

Background: This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment
of migraine. Methods: Multicenter, double-blind, randomized, placebo-controlled, parallel-…

Background Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an
increased risk of thrombotic events, but only limited long-term data have been available for …

N umerous studies of the relationship between facial profiles and dental occlusion have
appeared in the orthodontic literature. I-’Studies have also been made of orthodontists’ …

Background Calcitonin gene-related peptide (CGRP) probably has a role in migraine
pathophysiology, and antagonism of its receptors might provide treatment without the …