Acute induction of oncogenic Ras provokes cellular senescence involving the retinoblastoma
(Rb) pathway, but the tumour suppressive potential of senescence in vivo remains elusive. …

The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to
early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor …

HIV entry into CD4 + cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …

Background & Aims: Regulatory CD25+ T cells (T reg ) are effective in the prevention and
down-regulation of inflammatory bowel disease (IBD) in animal models. Functional T reg cells …

Histomorphology remains a powerful routine evaluating intestinal inflammation in animal
models. Emphasizing the focus of a given animal study, histopathology can overstate …

100 years after its first description by George H Whipple, the diagnosis and treatment of
Whipple's disease is still a subject of controversy. Whipple's disease is a chronic multisystemic …

Regulatory T-cells (Treg) have been the focus of immunologic research due to their role in
establishing tolerance for harmless antigens versus allowing immune responses against foes. …

After being activated by antigen, helper T lymphocytes switch from a resting state to clonal
expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of …

Introduction In this study, we analysed the number of IL-17 + cells in facet joints, in the
peripheral blood (PB) and synovial fluid (SF) of spondyloarthritis (SpA) patients and compared …

Peroral infection with Toxoplasma gondii leads to the development of small intestinal
inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report …