The introduction of biologics, especially tumour necrosis factor (TNF) inhibitors, has
revolutionized the management of chronic inflammatory diseases. However, at least one third of …

The development of drug-induced lupus remains a matter of concern in patients treated with
anti-tumour necrosis factor (TNF) alpha. The incidence of such adverse effects is unknown. …

Considering the special relation of human multiple myeloma (MM) to bones, it is of importance
to clarify the early steps of bone involvement in this disease. In this work, using bone …

OBJECTIVES: To update the evidence-based position statement published by the French
National Authority for Health (HAS) in 2006 regarding the pharmacological treatment of …

In order to clarify the mechanisms involved in the occurrence of lytic bone lesions (BL) in
multiple myeloma (MM), we have compared the presenting myeloma-induced histological bone …

The frequency and characteristics of definite lumbar scoliosis in an adult common low-back
pain population (n= 671) were assessed by a clinical and radiologic prospective study. The …

Objectives To evaluate the efficacy and safety of rituximab in patients with primary Sjögren's
syndrome (pSS). Methods The AutoImmune and Rituximab registry has included 86 patients …

Background Nonspecific back pain in children is nearly as common as in adults but is
associated with a number of age-specific risk factors including female gender, a family history of …

Importance One-third of patients with rheumatoid arthritis show inadequate response to tumor
necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists. …

Objective Continuous treatment with the anti–tumor necrosis factor α (anti‐TNFα) antibody
infliximab is efficacious in ankylosing spondylitis (AS), whereas treatment discontinuation …