User profiles for Chikao Morimoto

Chikao Morimoto

Professor Emeritus University of Tokyo Professor of Juntendo University
Verified email at ims.u-tokyo.ac.jp
Cited by 32658

Direct association of adenosine deaminase with a T cell activation antigen, CD26

…, T Tanaka, Y Nojima, SF Schlossman, C Morimoto - Science, 1993 - science.org
CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton
protein. Amino acid sequence analysis and immunoprecipitation studies …

Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects

…, E Kumagai, A Kondo, S Iwata, C Morimoto - Journal of …, 2010 - Elsevier
AIM OF THE STUDY: Various parts of Carica papaya Linn. (CP) have been traditionally used
as ethnomedicine for a number of disorders, including cancer. There have been anecdotes …

The structure and function of CD26 in the T‐cell immune response

C Morimoto, SF Schlossman - Immunological reviews, 1998 - Wiley Online Library
CD26 is a widely distributed 110 kD cell‐surface glycoprotein with known dipeptidyl‐peptidase
IV (DPP‐IV) activity in its extracellular domain. This ectoenzyme is capable of cleaving …

[PDF][PDF] Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle

…, M Sano, K Fukuda, M Suematsu, C Morimoto… - Cell metabolism, 2011 - cell.com
Maintenance of skeletal muscle mass relies on the dynamic balance between anabolic and
catabolic processes and is important for motility, systemic energy homeostasis, and viability. …

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

…, K Sugita, AS Freedman, C Morimoto… - Proceedings of the …, 1991 - National Acad Sciences
Occupancy of the T-cell receptor complex does not appear to be a sufficient stimulus to
induce a T-cell-mediated immune response. Increasing evidence suggests that cognate cell-cell …

B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production

…, K Sugita, T Mori, T Kobata, C Morimoto… - European journal of …, 1997 - Wiley Online Library
B cell immunoglobulin production is regulated by helper T cells through direct interaction
and secreted cytokines. In the present study, we functionally analyzed CD27 in cord and …

[HTML][HTML] CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-κB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2 …

…, M Shindo, T Kobata, M Atsuta, C Morimoto… - Journal of Biological …, 1998 - ASBMB
CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily and is expressed
on T, B, and NK cells. The signal via CD27 plays pivotal roles in TT and TB cell interactions. …

Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice

…, Y Nagashima, K Amo, K Aoki, C Morimoto… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Diet composition alters the metabolic states of adipocytes and hepatocytes in
diabetes. The effects of dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue …

Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function

K Ohnuma, NH Dang, C Morimoto - Trends in immunology, 2008 - cell.com
The role of CD26 in human T cell biology is puzzling. Despite being extensively characterized,
it has been called ‘a moonlighting protein' since it has multifunctional effects, but a …

[PDF][PDF] The role of CD26/dipeptidyl peptidase IV in cancer

…, M Abe, Y Urasaki, K Ohnuma, C Morimoto… - Front …, 2008 - article.imrpress.com
Morimoto: CD26-mediated signaling for T cell activation occurs in lipid rafts through its
association with CD45RO. Proc Natl Acad Sci USA 98, 12138-12143 (2001) 27. Hegen, M, J …