[HTML][HTML] Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis

…, B Brezina, A Mazzetti, CA McAlear… - … England Journal of …, 2020 - Mass Medical Soc
Background More effective and safer treatments are needed for antineutrophil cytoplasmic
antibody (ANCA)–associated vasculitis. Methods We conducted a randomized trial with a 2-by…

A randomized, double‐blind trial of abatacept (CTLA‐4Ig) for the treatment of giant cell arteritis

…, AG Sreih, R Spiera, CA McAlear… - Arthritis & …, 2017 - Wiley Online Library
Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant cell
arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or relapsing …

[PDF][PDF] Identification of multiple genetic susceptibility loci in Takayasu arteritis

…, O Karadag, S Kiraz, CA Langford, CA McAlear… - The American Journal of …, 2013 - cell.com
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu
arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is …

[PDF][PDF] A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility

…, CL Koening, CA Langford, CA McAlear… - The American Journal of …, 2015 - cell.com
We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and …

Disease relapses among patients with giant cell arteritis: a prospective, longitudinal cohort study

…, K Maksimowicz-McKinnon, CA McAlear… - The Journal of …, 2015 - jrheum.org
Objective. To evaluate the frequency, timing, and clinical features of relapses in giant cell
arteritis (GCA). Methods. Patients with GCA enrolled in a prospective, multicenter, longitudinal …

A randomized, double‐blind trial of abatacept (CTLA‐4Ig) for the treatment of Takayasu arteritis

…, AG Sreih, R Spiera, CA McAlear… - Arthritis & …, 2017 - Wiley Online Library
Objective To compare the efficacy of abatacept to that of placebo for the treatment of
Takayasu arteritis (TAK). Methods In this multicenter trial, patients with newly diagnosed or …

An open-label trial of abatacept (CTLA4-IG) in non-severe relapsing granulomatosis with polyangiitis (Wegener's)

…, P Seo, D Cuthbertson, CA McAlear… - Annals of the …, 2014 - ard.bmj.com
Objectives To determine the safety and efficacy of abatacept in non-severe relapsing
granulomatosis with polyangiitis (Wegener's)(GPA). Methods An open-label trial of intravenous …

Patterns of arterial disease in Takayasu arteritis and giant cell arteritis

…, K Maksimowicz-McKinnon, CA McAlear… - Arthritis care & …, 2020 - Wiley Online Library
Objective To identify and validate, using computer‐driven methods, patterns of arterial disease
in Takayasu arteritis (TAK) and giant cell arteritis (GCA). Methods Patients with TAK or …

Cardiac involvement in granulomatosis with polyangiitis

…, CL Koening, CA Langford, CA McAlear… - The Journal of …, 2015 - jrheum.org
Objective. To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)–related
cardiac disease in a North American GPA cohort. Methods. Analysis was done of all …

[PDF][PDF] A genome-wide association study identifies risk alleles in plasminogen and P4HA2 associated with giant cell arteritis

…, KM Maksimowicz-McKinnon, CA McAlear… - The American Journal of …, 2017 - cell.com
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50
years in Western countries. To shed light onto the genetic background influencing …