ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X7-dependent process inducing bacterial death by phagosome-lysosome fusion
IP Fairbairn, CB Stober, DS Kumararatne… - The Journal of …, 2001 - journals.aai.org
Mycobacterium tuberculosis survives within host macrophages by actively inhibiting phagosome
fusion with lysosomes. Treatment of infected macrophages with ATP induces both cell …
fusion with lysosomes. Treatment of infected macrophages with ATP induces both cell …
IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection
CB Stober, UG Lange, M Roberts, A Alcami… - The Journal of …, 2005 - journals.aai.org
Leishmaniasis affects 12 million people, but there are no vaccines. Immunological correlates
of vaccine efficacy are unclear. Polarized Th1 vs Th2 responses in Leishmania major-…
of vaccine efficacy are unclear. Polarized Th1 vs Th2 responses in Leishmania major-…
From genome to vaccines for leishmaniasis: screening 100 novel vaccine candidates against murine Leishmania major infection
CB Stober, UG Lange, MTM Roberts, B Gilmartin… - Vaccine, 2006 - Elsevier
The genomic sequence of Leishmania major provides a rich source of vaccine candidates.
One hundred randomly selected amastigote-expressed genes were screened as DNA …
One hundred randomly selected amastigote-expressed genes were screened as DNA …
[HTML][HTML] Cytokine responses to novel antigens in an Indian population living in an area endemic for visceral leishmaniasis
Background There are no effective vaccines for visceral leishmaniasis (VL), a neglected
parasitic disease second only to malaria in global mortality. We previously identified 14 …
parasitic disease second only to malaria in global mortality. We previously identified 14 …
ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guerin within human macrophages is calcium dependent and associated with the acidification of …
CB Stober, DA Lammas, CM Li… - The Journal of …, 2001 - journals.aai.org
We previously demonstrated that extracellular ATP stimulated macrophage death and
mycobacterial killing within Mycobacterium bovis Bacille Calmette-Guérin (BCG)-infected human …
mycobacterial killing within Mycobacterium bovis Bacille Calmette-Guérin (BCG)-infected human …
Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function
CB Stober, S Brode, JK White, JF Popoff… - Infection and …, 2007 - Am Soc Microbiol
Solute carrier family 11 member a1 (Slc11a1; formerly Nramp1) encodes a late endosomal/lysosomal
protein/divalent cation transporter that regulates iron homeostasis in macrophages…
protein/divalent cation transporter that regulates iron homeostasis in macrophages…
Interleukin-4 (IL-4) and IL-10 Collude in Vaccine Failure for Novel Exacerbatory Antigens in Murine Leishmania major Infection
MTM Roberts, CB Stober, AN McKenzie… - Infection and …, 2005 - Am Soc Microbiol
Leishmaniasis affects 12 million people but there are no vaccines in routine use. Recently,
we used DNA vaccination in a susceptible BALB/c high-dose model of infection to screen 100 …
we used DNA vaccination in a susceptible BALB/c high-dose model of infection to screen 100 …
DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major …
…, P Mastroeni, JM Blackwell, CB Stober - Infection and …, 2004 - Am Soc Microbiol
Successful resolution of infections by intracellular pathogens requires gamma interferon (IFN-γ).
DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) …
DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) …
Heterologous priming-boosting with DNA and modified vaccinia virus Ankara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania …
CB Stober, UG Lange, MTM Roberts… - Infection and …, 2007 - Am Soc Microbiol
Leishmaniasis affects 12 million people, but there are no vaccines in routine clinical use.
Th1 polarizing vaccines that elicit long-term protection are required to prevent disease in …
Th1 polarizing vaccines that elicit long-term protection are required to prevent disease in …
[HTML][HTML] Cytokine responses to novel antigens in a peri-urban population in Brazil exposed to Leishmania infantum chagasi
CB Stober, SMB Jeronimo, NN Pontes… - The American journal …, 2012 - ncbi.nlm.nih.gov
Visceral leishmaniasis (VL) is fatal if untreated, and there are no vaccines for this disease.
High levels of CD4-derived interferon-γ (IFN-γ) in the presence of low levels of interleukin-10 (…
High levels of CD4-derived interferon-γ (IFN-γ) in the presence of low levels of interleukin-10 (…