Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported
to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol …

Receptor-mediated transcytosis has been widely studied as a possible strategy to transport
neurotherapeutics across the blood−brain barrier (BBB). Monoclonal antibodies directed …

SAMP8 mice show several indicative characteristics of accelerated aging and have been
used to study the physiological and physiopathological processes that take place during …

Lafora disease (LD), the most devastating adolescence‐onset epilepsy, is caused by mutations
in the EPM2A or EPM2B genes, which encode the proteins laforin and malin, respectively…

The aim of this study was to determine the potential modulatory effects of diets supplemented
with spray-dried animal plasma (SDAP) or immunoglobulin concentrates (IC) on the …

This study was undertaken to investigate the potential role of cell cycle re-entry in an
experimental model of Huntington's disease and in human brain samples. We found that after …

Corpora amylacea (CA) have been described in several human organs and have been
associated with ageing and several pathological conditions. Although they were first discovered …

Corpora amylacea are structures of unknown origin and function that appear with age in human
brains and are profuse in selected brain areas in several neurodegenerative conditions. …

The development of inflammatory bowel disease may involve immune dysfunction. Because
enteral glutamine is the main source of amino acids for the intestinal mucosa and is …

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …