Evidence accumulated over more than 45 years has indicated that environmental stimuli
can induce craving for drugs of abuse in individuals who have addictive disorders. However, …

A defining feature of drug addiction is persistent drug use despite long-term adverse
consequences. This study examined the performance of drug abusers on a neuropsychological test …

Cocaine abusers demonstrate faulty decision-making as manifested by their inability to
discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an …

We have extended our previous work investigating the neural correlates of cue-induced cocaine
craving through the use of positron emission tomography with greater spatial resolution (…

As decision-making is central to motivated behavior, understanding its neural substrates can
help elucidate the deficits that characterize various maladaptive behaviors. Twenty healthy …

We evaluated the effects of the lipophilic nonpeptide corticotropin-releasing hormone (CRH)
type 1 receptor antagonist antalarmin on the behavioral, neuroendocrine, and autonomic …

OBJECTIVE: The study assessed the validity of the Gambling Task as a test of decision-making
ability in adolescents and examined whether adolescents with behavior disorders, who …

OBJECTIVE: The characteristics of attention deficit hyperactivity disorder (ADHD) include
abnormalities in reward responsivity that may interfere with decision making. The study …

The anterior cingulate cortex (ACC) and lateral prefrontal (LPFC) cortex are brain regions
important to executive cognitive functions (ECF). We determined ACC and LPFC function in 23-…

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to
cocaine-related cues to elicit drug craving. We measured the change of occupancy of …