Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity 1
. Herein we describe a new disease caused by high-penetrance heterozygous germline …

Objective Blocking interleukin‐1 with anakinra in patients with the autoinflammatory syndrome
neonatal‐onset multisystem inflammatory disease (NOMID) reduces systemic and organ‐…

Retinal vasculitis is an important entity for rheumatologists to understand. Retinal vasculitis
associated with Behçet's disease responds to monoclonal antibodies that neutralize TNF, but …

Objective To study efficacy and safety of escalating doses of canakinumab, a fully human
anti-IL-1β monoclonal antibody in the severe cryopyrin-associated periodic syndrome, neonatal…

Background The effect of IL-1 blocking therapy on mucocutaneous manifestations of Behçet’s
disease is incompletely understood. Methods Six patients with Behçet’s disease and …

Objective. To compare clinical manifestations and activity of Behçet syndrome (BS) in the
United States versus Turkey using validated outcome measures. Methods. Consecutive …

Objective To evaluate proinflammatory cytokines and leukocyte subpopulations in the
cerebrospinal fluid (CSF) and blood of patients with neonatal‐onset multisystem inflammatory …

Objectives To describe tracheobronchial disease in patients with granulomatosis with polyangiitis
(GPA) and evaluate the utility of dynamic expiratory CT to detect large-airway disease. …

Cryoglobulins consist of proteins (primarily immunoglobulins) that precipitate at temperatures
less than 37 C and resolubilize when blood is heated to more than 37 C. They develop …

Biopsies and ANCA testing for limited forms of granulomatosis with polyangiitis (GPA) are
frequently non-diagnostic. We characterized gene expression in GPA and other causes of …