Objective Blocking interleukin‐1 with anakinra in patients with the autoinflammatory syndrome
neonatal‐onset multisystem inflammatory disease (NOMID) reduces systemic and organ‐…

Retinal vasculitis is an important entity for rheumatologists to understand. Retinal vasculitis
associated with Behçet's disease responds to monoclonal antibodies that neutralize TNF, but …

Objective To study efficacy and safety of escalating doses of canakinumab, a fully human
anti-IL-1β monoclonal antibody in the severe cryopyrin-associated periodic syndrome, neonatal…

Background The effect of IL-1 blocking therapy on mucocutaneous manifestations of Behçet’s
disease is incompletely understood. Methods Six patients with Behçet’s disease and …

Objective To evaluate proinflammatory cytokines and leukocyte subpopulations in the
cerebrospinal fluid (CSF) and blood of patients with neonatal‐onset multisystem inflammatory …

Cryoglobulins consist of proteins (primarily immunoglobulins) that precipitate at temperatures
less than 37 C and resolubilize when blood is heated to more than 37 C. They develop …

Biopsies and ANCA testing for limited forms of granulomatosis with polyangiitis (GPA) are
frequently non-diagnostic. We characterized gene expression in GPA and other causes of …

Importance Sarcoidosis is a major cause of ocular or periocular inflammation. The
pathogenesis of sarcoidosis is incompletely understood and diagnosis often requires a biopsy. …

Orbital inflammatory diseases include thyroid eye disease (TED), granulomatosis with
polyangiitis (GPA), sarcoidosis, and nonspecific orbital inflammation (NSOI). Histopathological …

HLA-B27 associated disorders comprise a group of inflammatory conditions which have in
common an association with the HLA class I molecule, HLA-B27. Given this association, …