Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty
liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to …

Excessive dietary fructose intake may have an important role in the current epidemics of fatty
liver, obesity and diabetes as its intake parallels the development of these syndromes and …

Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic
syndrome, and nonalcoholic fatty liver disease. Fructose intake also causes features of …

The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has
been linked with recurrent dehydration. Here we tested whether recurrent dehydration may …

Diabetic retinopathy is the leading cause of blind-ness in the Western world (1) and is
character-ized by abnormal angiogenesis driven by several factors, including tissue ischemia and …

Introduction Immunotherapy targeting the programmed death 1 (PD-1)/programmed death
ligand 1 (PD-L1) checkpoint has shown promising efficacy in patients with NSCLC. …

Background. Recent studies suggest that uric acid is a mediator of diabetic nephropathy. We
hypothesized that elevated serum uric acid levels are a strong predictor of albuminuria in …

Controversy exists as to whether minimal change disease (MCD) and focal segmental
glomerulosclerosis (FSGS) represent different diseases or are manifestations within the same …

Fatty liver (hepatic steatosis) is associated with nucleotide turnover, loss of ATP and generation
of adenosine monophosphate (AMP). It is well known that in fatty liver, activity of the AMP…

Reduced AMP kinase (AMPK) activity has been shown to play a key deleterious role in
increased hepatic gluconeogenesis in diabetes, but the mechanism whereby this occurs remains …