Cartilage in normal and osteoarthritis conditions

J Martel-Pelletier, C Boileau, JP Pelletier… - Best practice & research …, 2008 - Elsevier
The preservation of articular cartilage depends on keeping the cartilage architecture intact.
Cartilage strength and function depend on both the properties of the tissue and on their …

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP …

JP Pelletier, C Boileau, J Brunet, M Boily… - Bone, 2004 - Elsevier
Objective: To evaluate the morphological changes that take place in the subchondral bone
and calcified cartilage zone in the experimental anterior cruciate ligament (ACL) dog model …

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

S Kwan Tat, N Amiable, JP Pelletier, C Boileau… - …, 2009 - academic.oup.com
Objectives. Earlier studies suggest the involvement of osteoprotegerin (OPG), RANK and
RANK ligand (RANKL) in OA subchondral bone metabolism; however, few studies have looked …

[HTML][HTML] Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide …

C Boileau, J Martel-Pelletier, J Caron, P Msika… - Arthritis research & …, 2009 - Springer
Introduction The aims of this study were, first, to investigate the in vivo effects of treatment with
avocado/soybean unsaponifiables on the development of osteoarthritic structural changes …

Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes …

G Tardif, D Hum, JP Pelletier, C Boileau… - … : Official Journal of …, 2004 - Wiley Online Library
Objective To compare gene expression in normal and osteoarthritic (OA) human chondrocytes
using microarray technology. Of the novel genes identified, we selected follistatin, a bone …

The peroxisome proliferator–activated receptor γ agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: In …

C Boileau, J Martel‐Pelletier, H Fahmi… - … : Official Journal of …, 2007 - Wiley Online Library
Objective Emerging evidence indicates that peroxisome proliferator–activated receptor γ (PPARγ)
may have protective effects in osteoarthritis (OA). The aim of this study was to evaluate …

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

…, DR Varma, F Gobeil Jr, C Beauséjour, C Boileau… - Nature medicine, 2014 - nature.com
Neurons have an important role in retinal vascular development. Here we show that the G
protein–coupled receptor (GPCR) coagulation factor II receptor-like 1 (F2rl1, previously known …

[HTML][HTML] Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible …

C Boileau, SK Tat, JP Pelletier, S Cheng… - Arthritis research & …, 2008 - Springer
Introduction Subchondral bone alterations represent an essential component of osteoarthritis
(OA). Modifying the abnormal subchondral bone metabolism may be indicated to treat OA. …

The in situ up‐regulation of chondrocyte interleukin‐1–converting enzyme and interleukin‐18 levels in experimental osteoarthritis is mediated by nitric oxide

C Boileau, J Martel‐Pelletier, F Moldovan… - Arthritis & …, 2002 - Wiley Online Library
Objective To investigate in situ the relationship between 2 key mediators implicated in
osteoarthritic (OA) cartilage: nitric oxide (NO) and interleukin‐1–converting enzyme (ICE). …

Limitation of the in vitro whole blood assay for predicting the COX selectivity of NSAIDs in clinical use

H Blain, C Boileau, F Lapicque… - British journal of …, 2002 - Wiley Online Library
Aims To assess if the inhibitory potency of nonsteroidal anti‐inflammatory drugs (NSAIDs)
on cyclooxygenase (COX) isoenzymes, when given therapeutically in humans, can be …