Objective: To test whether the association between initial serum lactate level and mortality in
patients presenting to the emergency department (ED) with severe sepsis is independent of …

Background: Acute respiratory distress syndrome (ARDS) is a serious complication of sepsis,
and sepsis-associated ARDS is associated with significant morbidity and mortality. To date, …

Rationale: The receptor for advanced glycation end products (RAGE) is an important marker
of lung epithelial injury and may be associated with impaired alveolar fluid clearance. We …

Primary graft dysfunction (PGD) after lung transplantation causes significant morbidity and
mortality. We aimed to determine the role of cytokines and chemokines in PGD. This is a …

Background Protocol-driven early goal-directed therapy (EGDT) has been shown to reduce
mortality in patients with severe sepsis and septic shock in the ED. EGDT appears to be …

PURPOSE: Endocan is a proteoglycan expressed by endothelial cells in the lung that may
inhibit leukocyte recruitment and thus prevent the development of acute lung injury (ALI). We …

Background: Single nucleotide polymorphisms in the myosin light chain kinase (MYLK)
gene have been implicated in the risk of sepsis-related acute lung injury and asthma. MYLK …

Objective: The additional impact of development of acute lung injury on mortality in severely-injured
trauma patients beyond baseline severity of illness has been questioned. We …

Background RBC transfusion has been associated with increased morbidity and mortality in
a variety of clinical settings. We assessed the effect of RBC transfusion on in-hospital …

Objective: We sought to develop a simple point score that would accurately capture the risk
of hospital death for patients with acute lung injury (ALI). Design: This is a secondary …