Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn,
the metabolic syndrome has been epidemiologically linked with renal progression. The …

Increased fructose consumption is associated with hyperuricemia, metabolic syndrome, and
renal damage. This study evaluated whether febuxostat (Fx), an investigational nonpurine, …

Experimental hyperuricemia (HU) results in preglomerular arteriolopathy, cortical
vasoconstriction, and glomerular hypertension. Recently, uric acid has been shown to induce …

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders.
Podocyte foot processes and the interposed glomerular slit diaphragm are essential …

… Sanchez-Lozada , Edilia Tapia , Jose Santamaria , Carmen Avila-Casado , Virgilia Soto ,
Tomas Nepomuceno , Bernardo Rodriguez-Iturbe , Richard J. Johnson, Jaime Herrera-Acosta …

Mildly hyperuricemic rats develop renin-dependent hypertension and interstitial renal disease.
Hyperuricemia might also induce changes in glomerular hemodynamics. Micropuncture …

Endothelial dysfunction is a characteristic feature during the renal damage induced by mild
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …

Background B-cell anomalies play a role in the pathogenesis of membranous nephropathy.
B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination of …

The main manifestations of nephrotic syndrome include proteinuria, hypoalbuminemia,
edema, hyperlipidemia and lipiduria. Common causes of nephrotic syndrome are diabetic …