The chronic nature of rheumatoid arthritis (RA) means that patients require drug therapy for
many years. Many RA patients, however, have to discontinue treatment because of drug-…

Objective Autoantibodies have been demonstrated in single serum samples from healthy
subjects up to 10 years before they developed rheumatoid arthritis (RA). However, the time …

Background The value of intensive combination therapy in early rheumatoid arthritis is
unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the …

… Dijkmans and Dougados have received consulting fees from Abbott. Drs. Wong and Kupper
… Dijkmans and Dougados have received consulting fees from Abbott. Drs. Wong and Kupper …

Methods. All patients had participated in the 56-week COBRA trial. During followup, they were
seen by their own rheumatologists and were also assessed regularly by study nurses; no …

Over the last decade, several new drugs have become available for the treatment of patients
with rheumatoid arthritis. These agents include the new disease-modifying antirheumatic …

Context Short-term data on the immunogenicity of monoclonal antibodies showed associations
between the development of antidrug antibodies and diminished serum drug levels, and …

Clinicians need to be aware of the risk of adverse outcome of parvovirus B19 infection in
pregnancy, and sometimes the long interval between exposure and fetal symptoms. Accurate …

Background: A substantial proportion of patients with rheumatoid arthritis (RA) do not respond,
or lose initial response, to adalimumab treatment. One explanation for non-response is …

Objective. To determine the efficacy of minocycline in the treatment of rheumatoid arthritis (RA).
Methods. Minocycline (maximal oral daily dose 200 mg) or placebo was administered in …