WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Interleukin (IL)‐6 is a cytokine
known for pleiotropic and pro‐inflammatory functions. IL‐6 is involved in various disease …

Objective We undertook a 2‐part, phase I, double‐blind, placebo‐controlled study to evaluate
the safety and pharmacokinetics of multiple intravenous infusions of sirukumab, a human …

OBJECTIVE: To assess safety, clinical response, and pharmacokinetics of subcutaneous (SC)
and intramuscular (IM) doses of an experimental formulation of infliximab [including …

Aims To assess the safety, tolerability, pharmacokinetics ( PK ), pharmacodynamics (PD) and
immunogenicity of CNTO 5825 following single‐dose intravenous (iv) and subcutaneous (…

Background Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease
characterized by pathogenic autoantibodies and tissue damage to multiple organ systems. …

Background Autoantibody-mediated diseases, such as systemic lupus erythematosus (SLE),
are caused by pathogenic antibodies that can damage tissues or organs. Approved …

Previously, we showed that ex vivo release of TNF by peripheral blood monocytes is a
biological marker for progression of Coal Workers' Pneumoconiosis (CWP), and suggested that …

… Fang Liu-Walsh Employee of: Janssen Research & Development, LLC and may own
stock or stock options in Johnson & Johnson., Bart van Hartingsveldt Employee of: Janssen …

Phytase catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol
and inorganic phosphate. A gene (phyA) of Aspergillus niger NRRL3135 coding for …

We investigated the predictive value of a new kindergarten assessment of handwriting readiness
on handwriting performance in first grade as evaluated by the Systematic Screening for …