The classical view of B cells in the biology of autoimmune responses to infectious and self-antigens
(Ag) that they promote immunity primarily by producing antibodies (Ab) is far from …

Objective. To identify the cells that produce BAFF in the salivary glands of patients with
primary Sjögren’s syndrome (SS), and to analyze BAFF receptor expression by local T and B …

Objective. Treatment with rituximab depletes B cells from the peripheral blood (PB) and
salivary glands (SGs) of patients with primary Sjögren’s syndrome (SS). The purpose of this …

The B-cell activating factor belonging to the tumor-necrosis factor family BAFF contributes to
autoimmune disorders. As such, BAFF might become a therapeutic target. However, this …

The presence of natural autoantibodies against cytokines has been reported in healthy
individuals. Because circulating cytokines may be implicated in the clinical outcome of numerous …

Objective To determine whether levels of B cell activating factor (BAFF), a member of the
tumor necrosis factor family, relate to autoantibody levels, disease activity, and response to …

Background Follicular helper T (T FH ) cells support terminal B-cell differentiation. Human
regulatory B (Breg) cells modulate cellular responses, but their control of T FH cell–dependent …

OBJECTIVE: To compare the diagnostic values of antiperinuclear factor (APF), antikeratin
antibody (AKA), and anti-cyclic citrullinated peptides (anti-CCP) to discriminate between …

Abatacept is a fusion protein (CTLA4-Ig) and therapeutic molecule labeled for the treatment
of rheumatoid arthritis (RA). Abatacept acts both by disrupting the CD28-mediated activation …

Intravenous immunoglobulin (IVIg) has been used to treat autoimmune diseases and lymphoid
malignancies with some therapeutic effect. In both these pathological conditions, there is …