Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
A Yoshizaki, T Miyagaki, DJ DiLillo, T Matsushita… - Nature, 2012 - nature.com
B cells regulate immune responses by producing antigen-specific antibodies 1 . However,
specific B-cell subsets can also negatively regulate T-cell immune responses, and have been …
specific B-cell subsets can also negatively regulate T-cell immune responses, and have been …
[HTML][HTML] IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
I Kalampokis, A Yoshizaki, TF Tedder - Arthritis research & therapy, 2013 - Springer
B cell abnormalities contribute to the development and progress of autoimmune disease.Traditionally,
the role of B cells in autoimmune disease was thought to be predominantly limited …
the role of B cells in autoimmune disease was thought to be predominantly limited …
Pathogenic roles of B lymphocytes in systemic sclerosis
A Yoshizaki - Immunology Letters, 2018 - Elsevier
Systemic sclerosis (SSc) is a collagen disease characterized by autoimmunity and excessive
extracellular matrix deposition in the skin and visceral organs. Although the pathogenic …
extracellular matrix deposition in the skin and visceral organs. Although the pathogenic …
CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
A Yoshizaki, Y Iwata, K Komura, F Ogawa… - The American journal of …, 2008 - Elsevier
Mice subcutaneously injected with bleomycin, in an experimental model of human systemic
sclerosis, develop cutaneous and lung fibrosis with autoantibody production. CD19 is a …
sclerosis, develop cutaneous and lung fibrosis with autoantibody production. CD19 is a …
[HTML][HTML] New era in systemic sclerosis treatment: recently approved therapeutics
…, A Yoshizaki-Ogawa, S Sato, A Yoshizaki - Journal of Clinical …, 2022 - mdpi.com
Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the
various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and …
various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and …
Activation of STAT3 is a marker of poor prognosis in human colorectal cancer
…, K Yamazumi, Y Yakata, A Yoshizaki… - Oncology …, 2006 - spandidos-publications.com
It is known that the signal transducer and activator of transcription 3 (STAT3) is a key signaling
molecule implicated in the regulation of growth and malignant transformation. Constitutive …
molecule implicated in the regulation of growth and malignant transformation. Constitutive …
Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial
Background Systemic sclerosis is a connective tissue disease characterised by multiorgan
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
…, K Yamazumi, Y Yakata, A Yoshizaki… - Journal of clinical …, 2005 - jcp.bmj.com
Background: The signal transducer and activator of transcription 3 (STAT3) is a key signalling
molecule implicated in the regulation of growth and malignant transformation. Constitutive …
molecule implicated in the regulation of growth and malignant transformation. Constitutive …
[HTML][HTML] IL-10–producing regulatory B10 cells inhibit intestinal injury in a mouse model
K Yanaba, A Yoshizaki, Y Asano, T Kadono… - The American journal of …, 2011 - Elsevier
B cells mediate multiple functions that influence immune and inflammatory responses. In
mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate …
mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate …
Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function
DJ DiLillo, JB Weinberg, A Yoshizaki, M Horikawa… - Leukemia, 2013 - nature.com
Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and
CLL cells share multiple phenotypic markers with regulatory B cells that are competent to …
CLL cells share multiple phenotypic markers with regulatory B cells that are competent to …