Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic
diversity depends on a comprehensive and reliable characterization of both sequences …

We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders,
for association with gout and serum uric acid levels. Genotypes were imputed into 41,675 …

Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable
1 . Here, by using a genome-wide association study of 30,234 cases and 725,172 controls …

Objective Patients with ankylosing spondylitis (AS) and ∼50% of their first‐degree relatives
may have a genetic abnormality that results in subclinical intestinal inflammation. This study …

Background & Aims : It has been suggested that subclinical intestinal inflammation plays a
pathogenic role in the spondylarthropathy of ankylosing spondylitis (AS). We assessed the …

A meta-analysis of publicly available summary statistics on multiple sclerosis combined with
three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven …

Platelets play an important role in hemostasis and other aspects of vascular biology. We
conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and …

Background: Alpha-fetoprotein (AFP), cancer antigens 15.3, 19.9, and 125, carcinoembryonic
antigen, and alkaline phosphatase (ALP) are widely measured in attempts to detect cancer …

Objective. Reactive arthritis (ReA) is a spondyloarthritis triggered by a bacterial infection. In
cases where nonsteroidal antiinflammatory drugs and conventional synthetic disease-…

Figure 1. Neutrophil and monocyte counts in relation to various treatment modalities in a 56-year-old
woman with a Z-year htstory ot Felty’s syndrome, persistent leukopenia, and …