Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
…, JM Saucier, JBL Pecq, AK Larsen - Cancer research, 1989 - AACR
Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation
which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. …
which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. …
Catalytic topoisomerase II inhibitors in cancer therapy
AK Larsen, AE Escargueil, A Skladanowski - Pharmacology & therapeutics, 2003 - Elsevier
The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All
topoisomerase II-directed agents are able to interfere with at least one step of the catalytic cycle…
topoisomerase II-directed agents are able to interfere with at least one step of the catalytic cycle…
Resistance mechanisms associated with altered intracellular distribution of anticancer agents
AK Larsen, AE Escargueil, A Skladanowski - Pharmacology & therapeutics, 2000 - Elsevier
The resistance of tumor cells to anticancer agents remains a major cause of treatment failure
in cancer patients. The term multidrug resistance (MDR) is used to define a resistance …
in cancer patients. The term multidrug resistance (MDR) is used to define a resistance …
[PDF][PDF] Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study
…, M Flesch, O Dupuis, P Colin, AK Larsen… - Journal of Clinical …, 2009 - researchgate.net
… Benoist Chibaudel, Frédérique Maindrault-Goebel, Gérard Lledo, Laurent Mineur,
Thierry André, Mostepha Bennamoun, May Mabro, Pascal Artru, Elisabeth Carola, Michel …
Thierry André, Mostepha Bennamoun, May Mabro, Pascal Artru, Elisabeth Carola, Michel …
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell–mediated lysis
…, P Bertheau, C Badoual, P Vielh, AK Larsen… - Cancer research, 2013 - AACR
Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and
drug resistance, but its impact on immune surveillance has not been explored. In this study, …
drug resistance, but its impact on immune surveillance has not been explored. In this study, …
Targeting EGFR and VEGF (R) pathway cross-talk in tumor survival and angiogenesis
AK Larsen, D Ouaret, K El Ouadrani… - Pharmacology & …, 2011 - Elsevier
… Author links open overlay panel Annette K. Larsen a b c , Djamila Ouaret a b c , Karima El …
and no detectable influence on the intracellular fraction (Larsen et al., 2011). Importantly, the …
and no detectable influence on the intracellular fraction (Larsen et al., 2011). Importantly, the …
A predictive score for thrombosis associated with breast, colorectal, lung, or ovarian cancer: the prospective COMPASS–Cancer‐Associated thrombosis study
…, AC Spyropoulos, S El Shemmari, AK Larsen… - The …, 2017 - academic.oup.com
Background The stratification of outpatients on chemotherapy for breast, colorectal, lung, and
ovarian cancers at risk of venous thromboembolism (VTE) remains an unmet clinical need. …
ovarian cancers at risk of venous thromboembolism (VTE) remains an unmet clinical need. …
Endomitosis of human megakaryocytes are due to abortive mitosis
…, JP LeCouedic, F Norol, AK Larsen… - Blood, The Journal …, 1998 - ashpublications.org
During megakaryocyte differentiation, the promegakaryoblast (immature megakaryocyte)
increases its ploidy to a 2 x DNA content by a poorly understood process called endomitosis. …
increases its ploidy to a 2 x DNA content by a poorly understood process called endomitosis. …
The role of cytokines in the regulation of NK cells in the tumor environment
GM Konjević, AM Vuletić, KMM Martinović, AK Larsen… - Cytokine, 2019 - Elsevier
Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis.
AB Larsen, RS Merkal, RC Cutlip - American journal of veterinary …, 1975 - europepmc.org
Two 1-month-old calves, four 9-month old calves, and 4 adult (5 to 11 years old) cattle were
exposed to Mycobacterium paratuberculosis. At 150 days after exposure, all cattle were …
exposed to Mycobacterium paratuberculosis. At 150 days after exposure, all cattle were …