Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

Background Chronic hepatitis C virus (HCV) infection in patients with stage 4–5 chronic
kidney disease increases the risk of death and renal graft failure, yet patients with hepatitis C …

Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However,
glucocorticoids used as treatment contribute to the morbidity and mortality of vasculitis. …

Introduction The previously reported randomised controlled trial of a consensus regimen of
pulse cyclophosphamide suggested that it was as effective as a daily oral (DO) …

Cerebral and myocardial ischemia, two of the leading causes of morbidity and mortality
worldwide, are associated with inflammation that can lead to multiple organ failure and death. …

BACKGROUND:: Plasma exchange may be effective adjunctive treatment for renal vasculitis.
We performed a systematic review and meta-analysis of randomized controlled trials of …

High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of
rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory …

Objectives Cyclophosphamide induction regimens are effective for antineutrophil
cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but are associated with infections, …

The consequences of the COVID-19 pandemic have been devastating; however, evidence
suggests that patients with, or at risk of, kidney disease are disproportionally affected. …

Patients with kidney diseases should be prioritized for COVID-19 vaccination and the available
data suggest that replication-defective viral-vectored vaccines and mRNA vaccines are …