CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, …

The identification of lymphocyte subsets with non-overlapping effector functions has been
pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (…

Human NK cells are divided into CD56 bright CD16− cells and CD56 dim CD16+ cells. We
tested the hypothesis that CD56 bright NK cells can differentiate into CD56 dim cells by …

To navigate into and within tissues, leukocytes require guidance cues that enable them to
recognize which tissues to enter and which to avoid. Such cues are partly provided at the time …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation …

Objective MicroRNA (miRNA) are recognized as important regulators of a variety of fundamental
biologic processes. Previously, we described increased expression of miR‐155 and miR…

Different subsets and/or polarized phenotypes of monocytes and macrophages may play
distinct roles during the development and resolution of inflammation. Here, we demonstrate in …

The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and
sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked …