Foxp3 plays a key role in CD4 + CD25 + T reg cell function in mice and represents a specific
marker for these cells. Despite the strong association between FOXP3 expression and …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Objective To investigate the association between weight or body mass index (BMI) and the
development of hand osteoarthritis. Methods Systematic review of observational studies. …

Background Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the
development of rheumatoid arthritis (RA). Objective To investigate whether the recognition …

Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and
knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects…

Dendritic cells (DCs) require a maturation signal to acquire efficient CTL-priming capacity.
In vitro FcγR-mediated internalization of Ag-Ab immune complexes (ICs) can induce …

Objective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid
arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a …

Objective Anti–citrullinated protein antibodies (ACPA) exhibit unique specificity for rheumatoid
arthritis. However, it is incompletely understood whether and how ACPA contribute to …

Human synovial fluid (SF) provides nutrition and lubrication to the articular cartilage. Particularly
in arthritic diseases, SF is extensively accumulating in the synovial junction. During the …

Objective Autoantibodies such as rheumatoid factor (RF) and anti–citrullinated protein
autoantibodies (ACPAs) determined by testing with second‐generation anti–cyclic citrullinated …