B7-1 and B7-2 are generally thought to have comparable structures and affinities for their
receptors, CD28 and CTLA-4, each of which is assumed to be bivalent. We show instead (1) …

According to the two-signal model of T cell activation, costimulatory molecules augment T
cell receptor (TCR) signaling, whereas adhesion molecules enhance TCR–MHC-peptide …

Bioluminescence resonance energy transfer (BRET), which relies on nonradiative energy
transfer between luciferase-coupled donors and GFP-coupled acceptors, is emerging as a …

Depression and falls have a significant bidirectional relationship. Excessive fear of falling,
which is frequently associated with depression, also increases the risk of falls. Both …

Objectives Good social connection is associated with better health and wellbeing. However,
social connection has distinct considerations for people living in long-term care (LTC) homes…

Like other developed countries, Canada has an aging population, although less than most
other G7 nations. Of a total population of 35 million people, 16.9% are aged 65 years or older …

Objective: Neuropsychiatric symptoms (NPS) may be the first manifestation of an underlying
neurocognitive disorder. We undertook a review to provide an update on the epidemiology …

Background Language impairment is an important marker of neurodegenerative disorders.
Despite this, there is no universal system of terminology used to describe these impairments …

OBJECTIVE: To clarify the role of sleep disorders, sleepiness, and depression in patients
with systemic lupus erythematosus (SLE) who complain of disabling tiredness. METHODS: …

Nursing homes are facing the rapid spread of COVID-19 among residents and staff and are
at the centre of the public health emergency due to the COVID-19 pandemic. As policy …