[HTML][HTML] Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions
MJ Del Rey, Á Valín, A Usategui, CM García-Herrero… - Scientific reports, 2017 - nature.com
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory
conditions. Besides, in normal O 2 environments, elevated rates of glycolysis support …
conditions. Besides, in normal O 2 environments, elevated rates of glycolysis support …
[HTML][HTML] Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
MJ Del Rey, Á Valín, A Usategui, S Ergueta, E Martín… - Immunity & …, 2019 - Springer
Background Accumulation of senescent cells has been associated with pro-inflammatory
effects with deleterious consequences in different human diseases. The purpose of this study …
effects with deleterious consequences in different human diseases. The purpose of this study …
Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia‐inducible transcription factor 1α/vascular …
…, E Izquierdo, S Caja, A Usategui… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Hyperplasia and phenotypic changes in fibroblasts are often observed in chronic
inflammatory lesions, and yet the autonomous pathogenic contribution of these changes is …
inflammatory lesions, and yet the autonomous pathogenic contribution of these changes is …
Synovial fibroblast hyperplasia in rheumatoid arthritis: clinicopathologic correlations and partial reversal by anti–tumor necrosis factor therapy
…, R Celis, MJ Del Rey, A Usategui… - Arthritis & …, 2011 - Wiley Online Library
Objective Synovial fibroblast (SF) hyperplasia contributes to the pathogenesis of rheumatoid
arthritis (RA), but quantitative information on this process is scarce. This study was …
arthritis (RA), but quantitative information on this process is scarce. This study was …
[HTML][HTML] Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients
J Ogando, M Tardáguila, A Díaz-Alderete, A Usategui… - Scientific reports, 2016 - nature.com
Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA)
pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine …
pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine …
[HTML][HTML] Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy
…, JD Canete, R Celis, B Santiago, A Usategui… - PLoS …, 2009 - journals.plos.org
Background Angiogenesis is considered an important factor in the pathogenesis of
Rheumatoid Arthritis (RA) where it has been proposed as a therapeutic target. In other settings, …
Rheumatoid Arthritis (RA) where it has been proposed as a therapeutic target. In other settings, …
[HTML][HTML] Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis
Á Domínguez-Soto, A Usategui, M Casas-Engel… - Scientific reports, 2017 - nature.com
Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in
numerous cell types through engagement of seven types of cell surface receptors (HTR1–7)…
numerous cell types through engagement of seven types of cell surface receptors (HTR1–7)…
[HTML][HTML] Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk
MJ Del Rey, R Fare, E Izquierdo, A Usategui… - PLoS …, 2014 - journals.plos.org
Introduction Synovial fibroblasts (SF) undergo phenotypic changes in rheumatoid arthritis (RA)
that contribute to inflammatory joint destruction. This study was undertaken to evaluate …
that contribute to inflammatory joint destruction. This study was undertaken to evaluate …
[HTML][HTML] Immunopathologic characterization of ultrasound-defined synovitis in rheumatoid arthritis patients in clinical remission
J Ramírez, R Celis, A Usategui, V Ruiz-Esquide… - Arthritis Research & …, 2016 - Springer
Background Patients with rheumatoid arthritis (RA) in clinical remission may have
ultrasound-defined synovitis according to the presence of power Doppler (PD) signal. The objective …
ultrasound-defined synovitis according to the presence of power Doppler (PD) signal. The objective …
The transcriptional response of normal and rheumatoid arthritis synovial fibroblasts to hypoxia
MJ Del Rey, E Izquierdo, A Usategui… - Arthritis & …, 2010 - Wiley Online Library
Objective Hypoxia is a prominent feature in rheumatoid arthritis (RA) synovium. However, its
contribution to the pathogenesis of RA remains unclear. We undertook this study to …
contribution to the pathogenesis of RA remains unclear. We undertook this study to …