WHEN activated, T helper cells differentiate into one of two subsets, Th1 and Th2, characterized
by distinct profiles of cytokine production. Th1 cells activate pro-inflammatory effector …

Constitutive expression of CD25, the IL‐2 receptor α‐chain, defines a distinct population of
CD4 + T cells (Treg) with suppressive activity in vitro and in vivo. IL‐2 has been implicated in …

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously
that the integrin α E β 7 discriminates distinct subsets of murine CD4 + regulatory T cells. Use …

Regulatory CD25 + CD4 + T cells are considered as important players in T cell homeostasis
and self-tolerance. Here we report that the integrin α E β 7 , which recognizes epithelial …

The direct assessment of T helper (T H )-cell responses specific for antigens is essential to
evaluate pathogenic and protective immunity. Presently, analysis and isolation of antigen-…

Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested multiple …

Apart from their classic genomic effects, it is well known that glucocorticoids also have rapid,
nongenomically mediated effects. Three different mechanisms are currently under …

Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

We analyzed for the first time the expression of chemokines in subpopulations of the murine
immune system at the single-cell level. We demonstrate in vitro and in a model of murine …

Th17 cells provide protection at barrier tissues but may also contribute to immune pathology.
The relevance and induction mechanisms of pathologic Th17 responses in humans are …