Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model
Acinetobacter baumannii , a Gram-negative multidrug-resistant (MDR) bacterium, is now
recognized as one of the more common nosocomial pathogens. Because most clinical isolates …
recognized as one of the more common nosocomial pathogens. Because most clinical isolates …
The monomer–dimer equilibrium of stromal cell‐derived factor‐1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin
CT Veldkamp, FC Peterson, AJ Pelzek… - Protein …, 2005 - Wiley Online Library
Chemokines, like stromal cell‐derived factor‐1 (SDF1/CXCL12), are small secreted proteins
that signal cells to migrate. Because SDF1 and its receptor CXCR4 play important roles in …
that signal cells to migrate. Because SDF1 and its receptor CXCR4 play important roles in …
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor
…, M Askenazi, BG Neel, AJ Pelzek… - Proceedings of the …, 2018 - National Acad Sciences
Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies
targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications. …
targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications. …
The 1.6 Å crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis
Lysins are peptidoglycan hydrolases that are produced by bacteriophage and act to lyse the
bacterial host cell wall during progeny phage release. Here, we describe the structure and …
bacterial host cell wall during progeny phage release. Here, we describe the structure and …
An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity
RL Tuinstra, FC Peterson, ES Elgin, AJ Pelzek… - Biochemistry, 2007 - ACS Publications
Chemokines adopt a conserved tertiary structure stabilized by two disulfide bridges and
direct the migration of leukocytes. Lymphotactin (Ltn) is a unique chemokine in that it contains …
direct the migration of leukocytes. Lymphotactin (Ltn) is a unique chemokine in that it contains …
Anti-carbamylated protein antibody levels correlate with anti-Sa (citrullinated vimentin) antibody levels in rheumatoid arthritis
GJ Challener, JD Jones, AJ Pelzek… - The Journal of …, 2016 - jrheum.org
Objective. The presence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis
(RA) indicates a breach in immune tolerance. Recent studies indicate that this breach …
(RA) indicates a breach in immune tolerance. Recent studies indicate that this breach …
[HTML][HTML] Use of a bacteriophage lysin to identify a novel target for antimicrobial development
We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor
thereof to which the organism did not spontaneously evolve measurable resistance. This …
thereof to which the organism did not spontaneously evolve measurable resistance. This …
The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Bacillus cereus Sensu Lato Isolates
Lytic bacteriophages (or phages) drive bacterial mortality by elaborating exquisite abilities
to bind, breach, and destroy bacterial cell membranes and subjugate critical bacterial cell …
to bind, breach, and destroy bacterial cell membranes and subjugate critical bacterial cell …
Persistence of Disease‐Associated Anti–Citrullinated Protein Antibody–Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission
AJ Pelzek, C Grönwall, P Rosenthal… - Arthritis & …, 2017 - Wiley Online Library
Objective In rheumatoid arthritis (RA), autoreactive B cells are pathogenic drivers and
sources of anti–citrullinated protein antibodies (ACPAs) that are a diagnostic biomarker and …
sources of anti–citrullinated protein antibodies (ACPAs) that are a diagnostic biomarker and …
[HTML][HTML] Hierarchy of human IgG recognition within the Staphylococcus aureus immunome
EE Radke, SM Brown, AJ Pelzek, Y Fulmer… - Scientific Reports, 2018 - nature.com
Staphylococcus aureus is an opportunistic pathogen that causes a range of serious
infections associated with significant morbidity, by strains increasingly resistant to antibiotics. …
infections associated with significant morbidity, by strains increasingly resistant to antibiotics. …