B cells regulate immune responses by producing antigen-specific antibodies 1 . However,
specific B-cell subsets can also negatively regulate T-cell immune responses, and have been …

B cell abnormalities contribute to the development and progress of autoimmune disease.Traditionally,
the role of B cells in autoimmune disease was thought to be predominantly limited …

Systemic sclerosis (SSc) is a collagen disease characterized by autoimmunity and excessive
extracellular matrix deposition in the skin and visceral organs. Although the pathogenic …

Mice subcutaneously injected with bleomycin, in an experimental model of human systemic
sclerosis, develop cutaneous and lung fibrosis with autoantibody production. CD19 is a …

Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the
various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and …

It is known that the signal transducer and activator of transcription 3 (STAT3) is a key signaling
molecule implicated in the regulation of growth and malignant transformation. Constitutive …

Background Systemic sclerosis is a connective tissue disease characterised by multiorgan
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …

Background: The signal transducer and activator of transcription 3 (STAT3) is a key signalling
molecule implicated in the regulation of growth and malignant transformation. Constitutive …

B cells mediate multiple functions that influence immune and inflammatory responses. In
mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate …

Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and
CLL cells share multiple phenotypic markers with regulatory B cells that are competent to …