The predictive role of antinuclear antibodies (ANAs) remains elusive in the long‐term outcome
of primary biliary cirrhosis (PBC). The progression of PBC was evaluated in association …

Background: Although the pathogenesis of non‐alcoholic steatohepatitis (NASH) remains
poorly understood, proinflammatory cytokines seem to play an important role in the process of …

Nodularin and microcystin-LR are cyanobacterial toxins and environmental hazards. Nodularin
inhibits protein phosphatases 1 and 2A with the same potency as does microcystin-LR, …

Green tea is now an acknowledged cancer preventive in Japan. This paper discusses several
important features of (−)-epigallocatechin gallate (EGCG), the main constituent of green …

The liver is an organ consisting of the largest reticulo-endothelial cell network in the body
and playing an important role in host defense against invading microorganisms. The organ is …

The Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein (WFA + ‐M2BP)
was recently shown to be a liver fibrosis glycobiomarker with a unique fibrosis‐related …

Tumor necrosis factor (TNF), a cytokine, and okadaic acid, a tumor promoter, strongly
phosphorylated the same proteins, vimentin and heat shock protein 27, although their time courses …

Background: Human intrahepatic biliary epithelial cells (HIBECs) may play active roles in both
the innate and adaptive immune responses. Little is known, however, about the role of toll‐…

(–)‐Epigallocatechin gallate (EGCG), the main constituent of green tea, and green tea extract
show growth inhibition of various cancer cell lines, such as lung, mammary, and stomach. …

The main physiologically active polyphenol in green tea extract is (−)-epigallocatechin gallate
(EGCG). Green tea extract has an advantage over EGCG as a cancer chemopreventive …