DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

…, LT Da Costa, E Rozenblum, CL Weinstein, A Fischer… - Science, 1996 - science.org
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To
identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were …

[HTML][HTML] Nintedanib for systemic sclerosis–associated interstitial lung disease

…, M Gahlemann, A Azuma, A Fischer… - … England Journal of …, 2019 - Mass Medical Soc
Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group …

…, J Dematte, ME Hinchcliff, A Fischer… - The lancet Respiratory …, 2016 - thelancet.com
Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However, …

An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features

A Fischer, KM Antoniou, KK Brown… - European …, 2015 - Eur Respiratory Soc
Many patients with an idiopathic interstitial pneumonia (IIP) have clinical features that suggest
an underlying autoimmune process but do not meet established criteria for a connective …

Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

AV Rubtsov, K Rubtsova, A Fischer… - Blood, The Journal …, 2011 - ashpublications.org
Females are more susceptible than males to many autoimmune diseases. The processes
causing this phenomenon are incompletely understood. Here, we demonstrate that aged …

Rheumatoid arthritis–interstitial lung disease–associated mortality

…, JJ Swigris, DB Sprunger, A Fischer… - American journal of …, 2011 - atsjournals.org
Rationale: Mortality rates from rheumatoid arthritis–associated interstitial lung disease (RA-ILD)
are largely unknown. Objectives: We sought to determine mortality rates from …

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial

TM Maher, TJ Corte, A Fischer, M Kreuter… - The lancet Respiratory …, 2020 - thelancet.com
Background At present, no approved pharmacotherapies are available for unclassifiable
interstitial lung disease (ILD), which is characterised by progressive fibrosis of the lung. We …

Interstitial lung disease in connective tissue disorders

A Fischer, R Du Bois - The lancet, 2012 - thelancet.com
Some of the most pressing challenges associated with interstitial lung disease (ILD) are
how best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD)—…

Mycophenolate mofetil improves lung function in connective tissue disease-associated interstitial lung disease

A Fischer, KK Brown, RM Du Bois, SK Frankel… - The Journal of …, 2013 - jrheum.org
Objective. Small series suggest mycophenolate mofetil (MMF) is well tolerated and may be
an effective therapy for connective tissue disease-associated interstitial lung disease (CTD-…

[HTML][HTML] MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

…, AD Walts, T Fingerlin, A Fischer… - … England Journal of …, 2018 - Mass Medical Soc
Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …