Objectives. To review studies that address prediction of response to biologic treatment in RA
and to explore the clinical utility of the studied (bio)markers. Methods. A search for relevant …

To improve patient function and possibly reduce disease progression, a biomechanical
approach should be considered in treating patients with osteoarthritis. Further research (…

Osteoarthritis, including osteoarthritis of the ankle, is diagnosed in the late stage of the disease
in most cases because of a lack of early markers. When clinically evident, osteoarthritis is …

Objective Osteoarthritis (OA) is a degenerative, disabling joint disease that affects >10% of
the adult population. No effective disease‐modifying treatment is available. In the present …

Background Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA).
Few options are available for treating end-stage knee OA other than joint replacement. …

Objective To predict response to anti–tumor necrosis factor (anti‐TNF) prior to treatment in
patients with rheumatoid arthritis (RA), and to comprehensively understand the mechanism of …

Objectives Osteoarthritis (OA) patient stratification is an important challenge to design
tailored treatments and drive drug development. Biochemical markers reflecting joint tissue …

OBJECTIVE: Radiography is still the golden standard for imaging features of osteoarthritis (OA),
such as joint space narrowing, subchondral sclerosis, and osteophyte formation. …

Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)
consortium intends to prospectively describe in detail, preselected patients with …

In clinical practice, approximately one-third of patients with rheumatoid arthritis (RA) respond
insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a …