Considerable progress has been made in identifying the transcription factors involved in the
early specification of the B-lymphocyte lineage. However, little is known about factors that …

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas.
Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed …

Objective To examine the degree to which shared risk factors explain the relationship of
periodontitis (PD) to rheumatoid arthritis (RA) and to determine the associations of PD and …

Background: Similarities exist in the epidemiology and immunopathogenesis of periodontitis
and rheumatoid arthritis (RA), but the associations between their respective disease …

Objective The co‐occurrence of rheumatoid factor (RF) and anti–citrullinated protein antibody
(ACPA) positivity in rheumatoid arthritis (RA) is well described. However, the mechanisms …

The tumor necrosis factor alpha (TNF-α) gene is rapidly activated by lipopolysaccharide (LPS).
Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but not …

ACTIVATING transcription factor-2 (ATF-2) is a basic region leucine zipper protein whose
DNA target sequence is the widely distributed cAMP response element (CRE). We report here …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized
by defective immune tolerance combined with immune cell hyperactivity resulting in the …

The objective of this study was to determine the prevalence of lupus-related autoimmunity in
a community-based cohort of over 3000 subjects, using a rheumatology registry as a …

The transcription factor human X-box binding protein 1 (hXBP-1) is a basic region-leucine
zipper protein implicated in the regulation of major histocompatibility complex class II gene …