Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …

Parkinson disease is a common neurodegenerative disorder that leads to difficulty in
effectively translating thought into action. Although it is known that dopaminergic neurons that …

Background Markers of γ-aminobutyric acid (GABA) neurotransmission seem to be altered in
the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether …

The results of a combined analysis and separate analyses of four multicenter, randomized,
parallel group studies that evaluated the effects of once‐daily topical administration of …

It is unclear to what degree antipsychotic therapy confounds longitudinal imaging studies
and post-mortem studies of subjects with schizophrenia. To investigate this problem, we …

Objective: Individuals with schizophrenia exhibit disturbances in a number of cognitive, affective,
sensory, and motor functions that depend on the circuitry of different cortical areas. The …

Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased
expression of GABA-related genes such as the 67 kDa isoform of glutamate decarboxylase (…

OBJECTIVE: Abnormalities in dopamine neurotransmission in the prefrontal cortex have
been implicated in the pathophysiology of schizophrenia. However, the integrity of the …

In the prefrontal cortex of subjects with schizophrenia, markers of the synthesis and re-uptake
of GABA appear to be selectively altered in a subset of interneurons that includes …

We have previously identified reductions in mean pyramidal cell somal volume in deep
layer 3 of BA 41 and 42 and reduced axon terminal density in deep layer 3 of BA 41. In other …