Analysis of Systemic Sclerosis-associated Genes in a Turkish Population

J Rheumatol. 2016 Jul;43(7):1376-9. doi: 10.3899/jrheum.160045. Epub 2016 May 1.

Abstract

Objective: To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.

Methods: There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations.

Results: Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E-05, OR 1.76; CD247: p = 2.20E-03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.

Conclusion: The genetic component of SSc seems to be similar between Turks and Europeans.

Keywords: GENETICS; SYSTEMIC SCLEROSIS; TURKEY.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles*
  • Autophagy-Related Protein 5 / genetics
  • CD3 Complex / genetics
  • Case-Control Studies
  • Endodeoxyribonucleases / genetics
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype*
  • Humans
  • Interferon Regulatory Factors / genetics
  • Interleukin-12 Subunit p35 / genetics
  • Male
  • Middle Aged
  • Phenotype*
  • Polymorphism, Single Nucleotide
  • STAT4 Transcription Factor / genetics
  • Scleroderma, Systemic / genetics*
  • Turkey

Substances

  • ATG5 protein, human
  • Autophagy-Related Protein 5
  • CD3 Complex
  • CD3 antigen, zeta chain
  • IL12A protein, human
  • IRF5 protein, human
  • Interferon Regulatory Factors
  • Interleukin-12 Subunit p35
  • STAT4 Transcription Factor
  • STAT4 protein, human
  • DNASE1L3 protein, human
  • Endodeoxyribonucleases