Objective: To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose.
Methods: In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation.
Results: Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes.
Conclusion: An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis.
Trial registration: Nederlands Trial Register; trial registration number: NTR2298.
Keywords: ARTHRITIS; DOSE-RESPONSE RELATIONSHIP; DRUG THERAPY; INJECTIONS; INTRAARTICULAR; TRIAMCINOLONE.