Granulocyte colony-stimulating factor induces disease flare in patients with antineutrophil cytoplasmic antibody-associated vasculitis

J Rheumatol. 2004 Aug;31(8):1655-8.

Abstract

Recombinant human granulocyte colony-stimulating factor (rhuG-CSF) is frequently given to patients with leukopenia or neutropenia caused by various underlying diseases. The treatment with rhuG-CSF is apparently safe, although cutaneous vasculitis and flares in patients with autoimmune diseases are described. We describe 2 patients with histologically proven antineutrophil cytoplasmic antibody-associated systemic vasculitis with disease flares after administration of rhuG-CSF, given to improve collection of stem cells prior to autologous stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / analysis*
  • Disease Progression
  • Female
  • Granulocyte Colony-Stimulating Factor / adverse effects*
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Lung / diagnostic imaging
  • Lung / drug effects
  • Male
  • Middle Aged
  • Orbit / diagnostic imaging
  • Orbit / drug effects
  • Radiography, Thoracic
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / therapeutic use
  • Tomography, Spiral Computed
  • Tomography, X-Ray Computed
  • Vasculitis / diagnostic imaging
  • Vasculitis / immunology
  • Vasculitis / physiopathology*

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor