Hypophyseal-pituitary-adrenal axis in autoimmune and rheumatic diseases

B H Athreya; P Rettig; W V Williams

doi:10.1007/BF02788752

Hypophyseal-pituitary-adrenal axis in autoimmune and rheumatic diseases

Immunol Res. 1998;18(2):93-102. doi: 10.1007/BF02788752.

Authors

B H Athreya¹, P Rettig, W V Williams

Affiliation

¹ A.I. duPont Institute of the Nemours Foundation, Pediatric Rheumatology, Wilmington, DE 19899, USA.

PMID: 9844828
DOI: 10.1007/BF02788752

Abstract

This article discusses the effects of sex steroids and anterior pituitary hormones on the immune system. Data from clinical and experimental studies on the effects of CRH, FSH, LH, and prolactin are reviewed. This is followed by a summary of results from our studies on the effects of FSH, LH, and prolactin on PBMC, CD4+ cells, and CD8+ cells in vitro.

Publication types

Review

MeSH terms

Adolescent
Arthritis, Juvenile / immunology
Autoimmune Diseases / immunology*
Corticotropin-Releasing Hormone / immunology
Female
Follicle Stimulating Hormone / immunology
Humans
Hypothalamo-Hypophyseal System / immunology*
Luteinizing Hormone / immunology
Male
Pituitary-Adrenal System / immunology*
Prolactin / immunology
Puberty / immunology
Rheumatic Diseases / immunology*
Sexual Maturation / immunology
T-Lymphocyte Subsets / drug effects

Substances

Prolactin
Luteinizing Hormone
Follicle Stimulating Hormone
Corticotropin-Releasing Hormone