Abstract
We investigated the rate of radiologic progression, as measured by carpal length, in 26 children with juvenile chronic arthritis who were treated with methotrexate. After 2 years of treatment, the carpal length was significantly more deteriorated in nonresponders in both the "better" wrist (P = .001) and the "worse" wrist (P = .005). These results show that methotrexate may have a "disease modifying" potential in juvenile chronic arthritis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antirheumatic Agents / therapeutic use*
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Arthritis, Juvenile / diagnostic imaging*
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Arthritis, Juvenile / drug therapy*
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Arthritis, Juvenile / physiopathology
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Carpal Bones / diagnostic imaging
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Carpal Bones / physiopathology
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Child
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Child, Preschool
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Disease Progression
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Female
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Humans
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Immunosuppressive Agents / therapeutic use*
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Infant
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Male
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Methotrexate / therapeutic use*
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Radiography
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Retrospective Studies
Substances
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Antirheumatic Agents
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Immunosuppressive Agents
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Methotrexate