Abstract
Microsomal and thyroglobulin autoantibody activity has been detected in synovial fluid from 34 of 50 patients with various arthritides (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis, and gout). Serum from only 4 of these patients showed thyroid-autoantibody activity, and the serum titres were considerably lower than the synovial-fluid titres. This suggests that thyroid autoantibody is produced locally in the joints of these patients.
MeSH terms
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Antibodies, Antinuclear / isolation & purification*
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Arthritis, Rheumatoid / immunology
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Autoimmune Diseases / immunology*
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Gout / immunology
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Humans
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Microsomes / immunology
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Osteoarthritis / immunology
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Rheumatic Diseases / immunology*
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Rheumatic Diseases / pathology
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Rheumatoid Factor / isolation & purification*
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Spondylitis, Ankylosing / immunology
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Synovial Fluid / cytology
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Synovial Fluid / immunology*
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Thyroglobulin / immunology*
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Thyroid Gland / pathology
Substances
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Antibodies, Antinuclear
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Rheumatoid Factor
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Thyroglobulin