Abstract
We critically reviewed the English language literature pertaining to drug-induced pancreatitis and attempted to determine whether the reported association between each drug and pancreatitis was valid. The following drugs seem to cause pancreatitis: azathioprine, thiazides, sulfonamides, furosemide, estrogens, and tetracycline. Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide. Evidence implicating other drugs is either inadequate or contradictory. Little is known about the pathogenesis of drug-induced pancreatitis. Ethanol was not considered in this review.
MeSH terms
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Acetaminophen / adverse effects
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Adrenal Cortex Hormones / adverse effects
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Amphetamines / adverse effects
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Asparaginase / adverse effects
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Azathioprine / adverse effects
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Chlorthalidone / adverse effects
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Cholestyramine Resin / adverse effects
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Cimetidine / adverse effects
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Cyproheptadine / adverse effects
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Dextropropoxyphene / adverse effects
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Diazoxide / adverse effects
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Diuretics
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Estrogens / adverse effects
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Ethacrynic Acid / adverse effects
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Furosemide / adverse effects
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Histamine / adverse effects
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Humans
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Hypercalcemia / complications
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Indomethacin / adverse effects
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Isoniazid / adverse effects
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Mercaptopurine / adverse effects
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Narcotics / adverse effects
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Pancreatitis / chemically induced*
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Phenformin / adverse effects
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Procainamide / adverse effects
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Rifampin / adverse effects
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Salicylates / adverse effects
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Sodium Chloride Symporter Inhibitors / adverse effects
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Sulfonamides / adverse effects
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Tetracycline / adverse effects
Substances
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Adrenal Cortex Hormones
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Amphetamines
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Diuretics
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Estrogens
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Narcotics
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Salicylates
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Sodium Chloride Symporter Inhibitors
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Sulfonamides
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Cholestyramine Resin
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Cyproheptadine
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Acetaminophen
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Furosemide
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Cimetidine
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Histamine
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Phenformin
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Mercaptopurine
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Asparaginase
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Tetracycline
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Procainamide
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Ethacrynic Acid
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Azathioprine
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Diazoxide
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Chlorthalidone
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Dextropropoxyphene
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Isoniazid
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Rifampin
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Indomethacin