The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells

Ann N Y Acad Sci. 1982 Dec 10:397:184-92. doi: 10.1111/j.1749-6632.1982.tb43426.x.
No abstract available

MeSH terms

  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Cell Division / drug effects*
  • Cell Line
  • Cells, Cultured
  • Chromatography, Gel
  • Female
  • Humans
  • Methotrexate / analogs & derivatives*
  • Methotrexate / biosynthesis
  • Methotrexate / metabolism
  • Peptide Biosynthesis*
  • Polyglutamic Acid / analogs & derivatives
  • Polyglutamic Acid / biosynthesis*
  • Tetrahydrofolate Dehydrogenase / metabolism
  • Time Factors

Substances

  • Polyglutamic Acid
  • methotrexate polyglutamate
  • Tetrahydrofolate Dehydrogenase
  • Methotrexate