Two experiments tested the hypothesis that laypeople cognitively organize and recall information about physical symptoms according to prototyped conceptions they have of physical diseases. Based on pilot studies that identified the extent to which subjects associated specified symptoms with specific diseases, symptom sets were assembled to vary in the extent to which the symptoms were perceived to be associated with (to be prototypical of) a given disease. Experiment 1 asked subjects to indicate whether a given set of symptoms indicated a disease and, if so, which one. Experiment 2 tested subjects' recall for symptom sets varying in prototypicality for given diseases and also tested the effects on recall of giving subjects a diagnosis. Results of both experiments support the prototype hypothesis that information about physical symptoms is organized and processed according to people's preexisting beliefs about the association between particular symptoms and diseases. Implications for illness behavior and help seeking are discussed.