Abstract
Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Autoantibodies / analysis*
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Autoantigens / immunology*
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Black People*
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Counterimmunoelectrophoresis
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Enzyme-Linked Immunosorbent Assay
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Humans
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Lupus Erythematosus, Systemic / genetics
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Lupus Erythematosus, Systemic / immunology*
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RNA, Small Cytoplasmic*
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Ribonucleoproteins*
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Ribonucleoproteins, Small Nuclear*
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SS-B Antigen
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White People*
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snRNP Core Proteins
Substances
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Autoantibodies
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Autoantigens
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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Ribonucleoproteins, Small Nuclear
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SS-A antigen
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snRNP Core Proteins