Abstract
The first reported case of Whipple's disease in a female who was HLA-B27 positive and had asymptomatic sacroiliitis is discussed. She presented great difficulty in diagnosis as she had multi-system involvement without diarrhea. This case supports the hypothesis that Whipple's disease is a disorder related to HLA-B27.
MeSH terms
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Anti-Infective Agents / therapeutic use
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Arthritis / complications
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Biopsy
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Chloramphenicol / therapeutic use
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Drug Combinations / therapeutic use
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Female
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HLA Antigens / analysis*
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HLA-B27 Antigen
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Humans
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Intestine, Small / pathology
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Lymph Nodes / ultrastructure
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Lymphadenitis / complications
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Middle Aged
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Radiography
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Sacroiliac Joint / diagnostic imaging
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Sex Factors
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Sulfamethoxazole / therapeutic use
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Trimethoprim / therapeutic use
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Trimethoprim, Sulfamethoxazole Drug Combination
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Whipple Disease / complications
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Whipple Disease / drug therapy
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Whipple Disease / immunology*
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Whipple Disease / pathology
Substances
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Anti-Infective Agents
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Drug Combinations
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HLA Antigens
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HLA-B27 Antigen
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Chloramphenicol
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Trimethoprim, Sulfamethoxazole Drug Combination
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Trimethoprim
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Sulfamethoxazole