Bone research in 2012: the ups and downs of bone in health and rheumatic disease

Nat Rev Rheumatol. 2013 Feb;9(2):67-8. doi: 10.1038/nrrheum.2012.219. Epub 2013 Jan 8.

Abstract

In 2012, several new concepts emerged that widen our view of the regulation of bone mass in health and disease. Three key studies outline these discoveries, which affect our understanding of the skeletal system, particularly its physiological function and the changes it undergoes during inflammatory disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Resorption / physiopathology*
  • Bone and Bones / physiology*
  • Bone and Bones / physiopathology*
  • Cell Differentiation / physiology
  • Homeostasis / physiology
  • Humans
  • Interleukin-23 / physiology
  • Osteoclasts / cytology
  • Osteogenesis / physiology*
  • Rheumatic Diseases / physiopathology*
  • Semaphorin-3A / physiology
  • Signal Transduction / physiology

Substances

  • Interleukin-23
  • Semaphorin-3A