Abstract
Warfarin is widely prescribed for patients with atrial fibrillation. In addition to unexpected bleeding, allergic skin reaction is one of its uncommon adverse effects. We herein report an 89-year-old man who, after taking warfarin for 4 years, suffered extensive skin eruptions. The skin biopsy disclosed leukocytoclastic vasculitis. The causal relationship between skin lesions and warfarin was confirmed after re-challenge of warfarin. A literature review revealed only 13 such cases reported from 1980 to 2011. Clinicians should be aware of this potential adverse effect of warfarin.
MeSH terms
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Acute Kidney Injury / chemically induced
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Aged, 80 and over
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Anticoagulants / adverse effects*
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Anticoagulants / therapeutic use
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Atrial Fibrillation / complications
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Coronary Disease / complications
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Drug Eruptions / etiology*
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Heart Failure / complications
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Humans
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Hypertension / complications
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Male
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Proteinuria / chemically induced
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Taiwan
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Thrombophilia / drug therapy
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Thrombophilia / etiology
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Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*
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Vasculitis, Leukocytoclastic, Cutaneous / diagnosis
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Warfarin / adverse effects*
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Warfarin / therapeutic use
Supplementary concepts
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Erythema elevatum diutinum